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Factor XII deficiency

Other Names for this Disease
  • Coagulation factor 12 deficiency
  • F12 deficiency
  • Factor 12 deficiency
  • HAF deficiency
  • Hageman factor deficiency
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Factor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting. While a lack of factor XII does not cause affected individuals to bleed abnormally, the blood takes longer than normal to clot in a test tube. The condition is usually discovered when prolonged clotting is noticed in the process of running other laboratory tests.[1] Factor XII deficiency is caused by mutations in the F12 gene. It is inherited in an autosomal recessive manner.[2] 
Last updated: 6/24/2011


  1. Dugdale DC, Chen YB. Factor XII (Hageman factor) deficiency. MedlinePlus. 2011; Accessed 6/24/2011.
  2. Factor XII Deficiency. Online Mendelian Inheritance in Man (OMIM). 2010; Accessed 6/24/2011.
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Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • MeSH® (Medical Subject Headings) is a terminology tool used by the National Library of Medicine. Click on the link to view information on this topic.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Factor XII deficiency. Click on the link to view a sample search on this topic.