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Other Names for this Disease
- Benign chronic pemphigus
- Benign familial pemphigus
- Familial benign pemphigus
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Hailey-Hailey disease is an inherited condition characterized by recurrent blisters seen primarily on the neck, groin, and axillae (armpit). Precipitating factors include heat, sweating, skin infection, and ultraviolet radiation. The disorder often becomes apparent after puberty, usually by the third or fourth decade, but symptoms can develop at any age. Hailey-Hailey disease occurs due to a mutation in a specific gene (ATP2C1) that creates a protein that is essential for skin health. There is no cure for this condition. Treatment is aimed at reducing symptoms and preventing flare-ups. This condition is inherited in an autosomal dominant fashion.
- Mauro T. Hailey-Hailey Disease. National Organization for Rare Disorders (NORD). http://rarediseases.org/rare-disease-information/rare-diseases/byID/1223/viewAbstract. Accessed July 25, 2011.
- Helm TN. Familial Benign Pemphigus (Hailey-Hailey Disease). eMedicine. http://emedicine.medscape.com/article/1063224-overview. Accessed July 25, 2011.
- Familial benign chronic pemphigus. Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=2841. Accessed July 25, 2011.
- Lamb S. Hailey-Hailey disease. DermNet NZ. http://www.dermnetnz.org/systemic/familial-pemphigus.html. Accessed July 25, 2011.
On this page
- DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition. Click on the link to view the information.
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge. Click on the link to read information on this topic.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Hailey-Hailey disease. Click on the link to view a sample search on this topic.
- The The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Hailey-Hailey disease. Click on the link to go to OMIM and review these resources.