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Genetic and Rare Diseases Information Center (GARD)

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Hemophilia A, congenital

Other Names for this Disease
  • Classic hemophilia
  • Factor 8 deficiency, congenital
  • Factor VIII deficiency, congenital
  • HEM A
  • Hemophilia, classic
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Your Question

I have severe hemophilia. How often do genetic mutations for severe hemophilia A occur - in caucasians, in women, and in America?  How common is type A versus type B or other types?  How common is the severe form as opposed to the moderate or mild forms?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

How rare is hemophilia A?

Globally, approximately one in 5000 males is born with hemophilia A.  Males of every ethnicity are equally affected.  For example, one in 5000 Hispanic males, one in 5000 African American males, and one in 5000 Caucasian males in the United States have this condition.[1]
Last updated: 3/11/2013

Can females be affected by hemophilia A?

Yes.  Approximately 10% of women who are carriers for hemophilia A are at risk for abnormal bleeding episodes.[2]  One study found that 5 out of 55 people with mild hemophilia A were female.[3]
Last updated: 3/12/2013

How common is hemophilia A compared to hemophilia B?

Hemophilia A affects one in 5000 individuals whereas hemophilia B affects one in 20,000.[3]
Last updated: 3/11/2013

What are the different forms of hemophilia A?

There are three forms of hemophilia A: severe, moderate, and mild.  Up to 70% of individuals with hemophilia A have the severe form, in which symptoms begin before age 1.  Symptoms of the moderate form of this disease begin between the ages of 1 and 2; at least 15% of affected individuals have the moderate form.  And at least 15% of individuals have the mild form, which begins at age 2 or older.[1]
Last updated: 3/12/2013