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Hemophilia A, congenital

Other Names for this Disease
  • Classic hemophilia
  • Factor 8 deficiency, congenital
  • Factor VIII deficiency, congenital
  • HEM A
  • Hemophilia, classic
More Names
Related Diseases
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Overview


Hemophilia A is a bleeding disorder that slows the blood clotting process. People with this condition experience prolonged bleeding or oozing following an injury, surgery, or having a tooth pulled. In severe cases of hemophilia, heavy bleeding occurs after minor trauma or even in the absence of injury (spontaneous bleeding). Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. Milder forms of hemophilia do not involve spontaneous bleeding, and the condition may not become apparent until abnormal bleeding occurs following surgery or a serious injury. Hemophilia A is inherited in an X-linked recessive fashion and is casued by mutations in the F8 gene.[1]

References

  1. Hemophilia. Genetics Home Reference. http://ghr.nlm.nih.gov/condition=hemophilia. Accessed June 16, 2011.
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General Information

  • The American Society of Gene & Cell Therapy provides information on the treatment of hemophilia.
  • Genetics Home Reference (GHR) contains information on Hemophilia A, congenital. Click on the link to go to GHR and review the information.
  • MedlinePlus, a Web site designed by the National Library of Medicine to help you research your health questions, provides more information about this topic. Click on the link to view this information.
  • The Merck Manuals Online Medical Library provides information on this condition. Click on the link to view the information.
  • The National Heart, Lung, and Blood Institute (NHLBI) provides leadership for a national program in diseases of the heart, blood vessels, lung, and blood; blood resources; and sleep disorders. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman's Health Initiative. Click on the link to view information on this topic.
  • The National Human Genome Research Institute's (NHGRI) mission encompasses a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. Click on the link to view the information page on this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.  Click on the link to read information on this topic.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Hemophilia A, congenital. Click on the link to view a sample search on this topic.
  • The The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Hemophilia A, congenital. Click on the link to go to OMIM and review these resources.