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Genetic and Rare Diseases Information Center (GARD)

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Hereditary amyloidosis

Other Names for this Disease
  • Amyloidosis hereditary
  • Familial amyloidosis
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How is hereditary amyloidosis inherited?

The hereditary amyloidoses are inherited in an autosomal dominant manner. This means that one altered copy of the disease-causing gene (called a mutation) in each cell is sufficient to cause the disease. The disease-causing mutation can be inherited from a parent or it can occur for the first time in an individual. Each child of an individual affected with hereditary amyloidosis has a 50% (1 in 2) risk to inherit the disease-causing mutation and a 50% chance of not inheriting the mutation. However, not all individuals with a mutation in a gene that causes hereditary amyloidosis will develop signs and symptoms of the disease.
Last updated: 9/16/2011