Other Names for this Disease
- Coproporphyria hereditary
- Coproporphyrinogen oxidase deficiency
- CPO deficiency
- CPRO deficiency
Acute attacks are characterized by abdominal pain, nausea, vomiting and loss of appetite. These symptoms are often accompanied by constipation and a fast pulse rate. The urine of individuals experiencing an attack may be dark or it may darken on standing, particularly in sunlight. In rare cases, changes in the level of consciousness and various abnormalities of mental function may occur along with muscle weakness which may become life-threatening. Between acute attacks, individuals are often symptom free.
The skin manifestations are similar to those in porphyria cutanea tarda. Blisters form in sun-exposed areas and can evolve into chronic scarred areas of fragile skin. Patients also may develop excessive hair growth in sun-exposed areas.
The Human Phenotype Ontology provides the following list of signs and symptoms for Hereditary coproporphyria. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.
The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.
The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.
Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.
- DeLoughery TG. Porphyria, Hereditary Coproporphyria. eMedicine. 2009; http://emedicine.medscape.com/article/205374-overview. Accessed 11/11/2010.
- Hereditary Coproporphyria. Canadian Porphyria Foundation. http://www.cpf-inc.ca/HCP.htm. Accessed 11/11/2010.