Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Hereditary spastic paraplegia


Other Names for this Disease

  • Familial spastic paraparesis
  • FSP
  • HSP
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Symptoms

Newline Maker

What are the symptoms of hereditary spastic paraplegia?

The main symptoms include a slow, progressive, spasticity and weakness of the legs that often gets severe, requiring assistive devices. There is also difficulty with balance, clumsiness, and often muscle spasms[1].
Last updated: 10/6/2011

The Human Phenotype Ontology provides the following list of signs and symptoms for Hereditary spastic paraplegia. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Gait disturbance 90%
Hemiplegia/hemiparesis 90%
Hypertonia 90%
Impaired pain sensation 90%
Incoordination 50%
Finger syndactyly 7.5%

Last updated: 9/2/2014

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. Fink JK. A Comparison of Hereditary Spastic Paraparesis (HSP) and Primary Lateral Sclerosis (PLS). Spastic Paraplegia Foundation, Inc.. November 22, 2013; http://sp-foundation.org/understanding-hsp-pls/overview-summary-chart/. Accessed 10/22/2014.


Other Names for this Disease
  • Familial spastic paraparesis
  • FSP
  • HSP
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.