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Genetic and Rare Diseases Information Center (GARD)

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Chronic hiccups

Other Names for this Disease
  • Hiccups, intractable
  • Intractable hiccups
  • Intractable singultus
  • Persistent hiccups
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How might chronic hiccups be treated?

The treatment of chronic hiccups depends on the cause. Hiccups associated with gastroesophageal reflux may be treated with antacids and omeprazole. Those found in association with central nervous system problems may be treated with Baclofen.[1] Other medications which may be used include chlorpromazine, gabapentin, valproate, and lidocaine bolus.[2] Very rarely, medical methods fail to treat persistent hiccups. Further treatment may include a phrenic nerve block. The phrenic nerve controls the diaphragm.[3]
Last updated: 2/20/2012

  1. Cabane J. Chronic hiccup. Orphanet. 2004; Accessed 11/28/2011.
  2. Lierz P, Felleiter P. Anesthesia as Therapy for Persistent Hiccups. Anestesia & Analgesia. 2002; Accessed 11/28/2011.
  3. Vorvick L. Hiccups. MedlinePlus. January 2011; Accessed 11/28/2011.

Clinical Trials & Research for this Disease

  • Orphanet lists clinical trials, research studies, and patient registries enrolling people with this condition. Click on Orphanet to view the list.