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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Mucopolysaccharidosis type II


Other Names for this Disease

  • Attenuated MPS (subtype; formerly known as mild MPS II)
  • Hunter syndrome
  • I2S deficiency
  • Iduronate 2-sulfatase deficiency
  • MPS 2
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Inheritance

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How is mucopolysaccharidosis II (MPS II) inherited?

MPS II is inherited in an X-linked recessive pattern, which means that this conditions occurs almost exclusively in males. Females are generally unaffected carriers of this condition. In a family with more than one affected individual, the mother of the affected males must be a carrier. When a carrier female has a child, there is a 25% (1 in 4) chance that she will have a affected son.[1]
Last updated: 9/20/2013

References
  1. Martin RA. Mucopolysaccharidosis Type II. Gene Reviews. November 6, 2007; http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=hunter. Accessed 12/29/2008.


Other Names for this Disease
  • Attenuated MPS (subtype; formerly known as mild MPS II)
  • Hunter syndrome
  • I2S deficiency
  • Iduronate 2-sulfatase deficiency
  • MPS 2
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.