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Hypokalemic periodic paralysis

Other Names for this Disease
  • HypoPP
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Hypokalemic periodic paralysis is a condition that causes episodes of extreme muscle weakness typically beginning in childhood or adolescence. Most often, these episodes involve a temporary inability to move muscles in the arms and legs. The duration and frequency of the episodes may vary. Hypokalemic periodic paralysis is caused by mutations in the CACNA1S and SCN4A genes which are inherited in an autosomal dominant fashion. A small percentage of people with the characteristic features of hypokalemic periodic paralysis do not have identified mutations in these genes. In these cases, the cause of the condition is unknown.[1] Paralytic crises can be treated with oral or IV potassium. Other management includes prevention of crises and support of specific symptoms.[2]
Last updated: 9/16/2009


  1. Hypokalemic periodic paralysis. Genetics Home Reference. April 2007; Accessed 4/20/2010.
  2. Sternberg D, Tabti N, Hainque B, Fontaine B. Hypokalemic periodic paralysis. GeneReviews. April 28, 2009; Accessed 4/20/2010.
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  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
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