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Genetic and Rare Diseases Information Center (GARD)

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Other Names for this Disease
  • Hypophosphatasia mild
  • Phosphoethanol-aminuria
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Your Question

My daughter has hypophosphatasia. She will soon be 7 years-old and has already lost eleven of her first teeth. Two of her adult teeth have come in. Will she loose these too?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Can hypophosphatasia cause the early loss of adult (or secondary) teeth?

Yes. Hypophosphatasia is a disorder that disrupts a process called mineralization, in which minerals such as calcium and phosphorus are deposited in developing bones and teeth. Mineralization is critical for the formation of teeth that can withstand chewing and grinding. Hypophosphatasia is characterized by the early loss of baby (or deciduous) teeth. While not as common, children and adults with hypophosphatasia may also have additional issues with their adult or permanent teeth. Problems may include cavity prone teeth and early loss of teeth.[1][2] Children and adults with hypophosphatasia benefit from consultations with an appropriate specialist for care of dentition (tooth) complications.
Last updated: 5/6/2009