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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Ichthyosis vulgaris


Other Names for this Disease

  • Common ichthyosis
  • Fish scale disease
  • Ichthyosis simplex
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Cause

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What causes ichthyosis vulgaris?

Ichthyosis vulgaris is caused by a genetic mutation. The mutated gene causes an abnormality in the normal lifecycle of skin. Whilst in most people, the growth, dying and shedding of skin happens unnoticed, people with ichthyosis reproduce new skin cells at a rate faster than they can shed it, or reproduce at a normal rate but the rate of shedding is too slow. Either way there is a build up of dry scaly skin. The mutated gene in ichthyosis vulgaris is found on chromosome 1q21 and is related to a protein called filaggrin.[1] To learn more about the protein filaggrin please click here.
Last updated: 10/18/2013

References
  1. Ichthyosis. DermNet NZ. January 2013; http://www.dermnetnz.org/scaly/ichthyosis.html. Accessed 1/24/2013.


Other Names for this Disease
  • Common ichthyosis
  • Fish scale disease
  • Ichthyosis simplex
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.