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Genetic and Rare Diseases Information Center (GARD)

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Intestinal pseudo-obstruction


Other Names for this Disease
  • Hollow visceral myopathy
  • Intestinal pseudoobstruction
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Overview


Intestinal pseudo-obstruction is a digestive disorder in which the intestinal walls are unable to contract normally (called hypomotility); the condition resembles a true obstruction, but no actual blockage exists. Signs and symptoms may include abdominal pain; vomiting; diarrhea; constipation; malabsorption of nutrients leading to weight loss and/or failure to thrive; and other symptoms. It may be classified as neuropathic (from lack of nerve function) or myopathic (from lack of muscle function), depending on the source of the abnormality.[1] The condition is sometimes inherited (in an X-linked recessive or autosomal dominant manner) and may be caused by mutations in the FLNA gene;[2] it may also be acquired after certain illnesses.[1] The goal of treatment is to provide relief from symptoms and ensure that nutritional support is adequate.[1]
Last updated: 5/10/2011

References

  1. Intestinal Pseudoobstruction. NORD. December 31, 2010; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Intestinal%20Pseudoobstruction. Accessed 5/10/2011.
  2. Intestinal pseudo-obstruction. Genetics Home Reference. October 2010; http://ghr.nlm.nih.gov/condition/intestinal-pseudo-obstruction. Accessed 5/10/2011.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Intestinal pseudo-obstruction. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC), part of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), conducts and supports research on a broad spectrum of diseases affecting public health. Click on the link to view information on this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Intestinal pseudo-obstruction. Click on the link to view a sample search on this topic.