Other Names for this Disease
- Continuous muscle fiber activity syndrome
- Isaac's-Merten's syndrome
- Quantal squander syndrome
- Seminoma of the testis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
Isaac's syndrome is a neuromuscular disease caused by continuous signaling of the end regions of peripheral nerve fibers that activate muscle fibers (motor neurons). Age of onset is between ages 15 and 60, with most patients experiencing symptoms before age 40. There are hereditary and acquired forms of the disorder. The acquired form may develop in association with peripheral neuropathies or as an autoimmune condition.
Last updated: 2/11/2010
- NINDS Isaac's Syndrome Information Page. National Institute of Neurological Disorders and Stroke (NINDS). 2009; http://www.ninds.nih.gov/disorders/isaacs_syndrome/isaacs_syndrome.htm. Accessed 2/11/2010.
- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Isaac's syndrome. Click on the link to view a sample search on this topic.