Autosomal dominant hyper IgE syndrome
Other Names for this Disease
- AD hyperimmunoglobulin E syndrome
- Autosomal dominant HIES
- Autosomal dominant hyper-IgE syndrome
- Autosomal dominant hyperimmunoglobulin E syndrome
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eczema, and occasionally bone and tooth abnormalities. The eczema and skin infections may cause rashes, blisters, collections of pus (abscesses), open sores, and scaling of the skin. Some cases of AD-HIES are caused by mutations in the STAT3 gene. In other cases, the cause is unknown.Autosomal dominant hyper IgE syndrome (AD-HIES), formerly known as Job syndrome, affects several body systems including the immune system. AD-HIES is characterized by abnormally high levels of an immune system protein called immunoglobulin E (IgE) in the blood. Signs and symptoms may include recurrent infections (e.g., pneumonia, skin infections),
Last updated: 8/25/2010
- Job syndrome. Genetics Home Reference (GHR). February 2008; http://ghr.nlm.nih.gov/condition=jobsyndrome. Accessed 11/13/2008.
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- DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
- Genetics Home Reference (GHR) contains information on Autosomal dominant hyper IgE syndrome. This website is maintained by the National Library of Medicine.
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- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
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