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Genetic and Rare Diseases Information Center (GARD)

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Kartagener syndrome

Other Names for this Disease
  • Dextrocardia bronchiectasis and sinusitis
  • Siewert syndrome
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What causes Kartagener syndrome?

Kartagener syndrome is caused by an inherited defective gene which causes the cilia to be either immotile (unable to move) or dysmotile (they move incorrectly). As a result, mucous cannot be cleared from the lungs, paranasal sinuses and ears. Bacteria and other irritants in the mucous lead to frequent respiratory infections.[1] Kartagener syndrome is inherited in an autosomal recessive manner. Recent studies have shown that Kartagener syndrome is linked to a region on chromosome 15q.[2] 
Last updated: 8/22/2011

  1. Zariwala M. Primary Ciliary Dyskinesia. National Organization for Rare Disorders (NORD). 2008; Accessed 10/13/2008.
  2. Geremek M, Schoenmaker F, Zietkiewicz E, Pogorzelski A, Diehl S, Wijmenga C, Witt M. Eur J Hum Genet. June 2008; Accessed 10/13/2008.