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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Kikuchi disease


Other Names for this Disease

  • Histiocytic necrotising lymphadenitis
  • Kikuchi necrotizing lymphadenitis
  • Kikuchi's disease
  • Kikuchi-Fujimoto's disease
  • Nosocomial Kikuchi's disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

What is Kikuchi disease?

How is Kikuchi disease diagnosed?

How might Kikuchi disease be treated?

What is the long-term outlook for people with Kikuchi disease?

What is Kikuchi disease?

Kikuchi disease is a benign (non-cancerous) condition of the lymph nodes. It is usually characterized by cervical lymphadenopathy (tender, swollen lymph nodes), mild fever, and night sweats. Less common symptoms include weight loss, nausea, vomiting, and sore throat.[1] While the exact cause of this condition has not been proven, infectious and autoimmune causes have been suggested, such as an immune response to a viral infection.[2][3] Treatment is symptomatic and supportive and may include pain relievers or non-steroidal anti-inflammatory drugs (NSAIDS), and corticosteroids in rare cases. Most cases go away on their own within 1 to 6 months.[1][2]
Last updated: 10/15/2014

How is Kikuchi disease diagnosed?

A diagnosis of Kikuchi disease can be confirmed only by excisional biopsy of the lymph node. Results of other types of laboratory tests and imaging studies may only be suggestive of the diagnosis, and may also be used to rule out other conditions.[4]

Additional information about the diagnosis of Kikuchi disease can be viewed on Medscape's Web site.

Last updated: 10/15/2014

How might Kikuchi disease be treated?

Kikuchi disease is typically self-limited, going away on its own within one to four months. However, treatment may relieve some of the signs and symptoms of the condition. Analgesics-antipyretics (drugs that relieve pain and fever) and nonsteroidal anti-inflammatory drugs (NSAIDs) may be used to ease lymph node tenderness and fever. The use of corticosteroids has been recommended in severe cases. Affected people should be followed for several years to rule out development of systemic lupus erythematosus (SLE).[5]

Additional information about the treatment of Kikuchi disease is available on Medscape Reference's Web site.
Last updated: 10/15/2014

What is the long-term outlook for people with Kikuchi disease?

Kikuchi disease generally has a good prognosis. Lymphadenopathy usually goes away 1-6 months after onset, although it may last longer. About 3% to 4% of people have recurrence of the condition. [1][2]

Some people go on to develop systemic lupus erythematous (SLE) (lupus) years later.[1][2] SLE is a chronic autoimmune disorder that may affect the skin, joints, kidneys, and other organs. Symptoms vary from person to person. Almost all people with SLE have joint pain and swelling. Some develop arthritis. Joints commonly affected include those of the fingers, hands, wrists, and knees. Other symptoms may include chest pain when taking a deep breath; general discomfort or ill feeling; and/or mouth sores.[6]
Last updated: 10/15/2014

References
  1. Bosch X & Guilabert A. Kikuchi-Fujimoto disease. Orphanet. 2006; http://www.ojrd.com/content/1/1/18 . Accessed 4/6/2011.
  2. Boone J, Kuzma CS. Kikuchi Disease. eMedicine. 2009; http://emedicine.medscape.com/article/210752-overview. Accessed 4/6/2011.
  3. Michael J. Richards. Kikuchi disease. UpToDate. Waltham, MA: UpToDate; October, 2014; Accessed 10/15/2014.
  4. John Boone. Kikuchi disease. Medscape. September 2, 2014; http://emedicine.medscape.com/article/210752-overview. Accessed 10/15/2014.
  5. Xavier Bosch and Antonio Guilabert. Kikuchi-Fujimoto disease. OJRD. 2006; 1:18:http://www.ojrd.com/content/1/1/18. Accessed 12/12/2012.
  6. Borigini MJ. Systemic lupus erythematosus. MedlinePlus. February 2010; http://www.nlm.nih.gov/medlineplus/ency/article/000435.htm. Accessed 4/6/2011.


Other Names for this Disease
  • Histiocytic necrotising lymphadenitis
  • Kikuchi necrotizing lymphadenitis
  • Kikuchi's disease
  • Kikuchi-Fujimoto's disease
  • Nosocomial Kikuchi's disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.