Other Names for this Disease
- Galactocerebrosidase deficiency
- Galactosylceramidase deficiency
- Galactosylceramide beta-galactosidase deficiency
- GALC deficiency
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Krabbe leukodystrophy is inherited in an autosomal recessive manner. If both parents are carriers (each having one working copy of the gene and one non-working copy), each child that they have has a 25% chance (1 in 4) of being affected (having the condition), a 50% chance (1 in 2) of being an asymptomatic carrier (like each parent), and a 25% chance of being unaffected (not having the condition) and also not being a carrier. If a sibling of a child with Krabbe leukodystrophy is already known to be unaffected, the chance of him/her being a carrier is 2/3.
Last updated: 11/23/2010
- David A Wenger. Krabbe disease. GeneReviews. August 5, 2008; http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=krabbe. Accessed 11/23/2010.