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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Krabbe leukodystrophy


Other Names for this Disease

  • Galactocerebrosidase deficiency
  • Galactosylceramide beta-galactosidase deficiency
  • GALC deficiency
  • GCL
  • GLD
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Inheritance

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How is Krabbe leukodystrophy inherited?

Krabbe leukodystrophy is inherited in an autosomal recessive manner. If both parents are carriers (each having one working copy of the gene and one non-working copy), each child that they have has a 25% chance (1 in 4) of being affected (having the condition), a 50% chance (1 in 2) of being an asymptomatic carrier (like each parent), and a 25% chance of being unaffected (not having the condition) and also not being a carrier. If a sibling of a child with Krabbe leukodystrophy is already known to be unaffected, the chance of him/her being a carrier is 2/3.[1]
Last updated: 11/23/2010

References
  1. David A Wenger. Krabbe disease. GeneReviews. August 5, 2008; http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=krabbe. Accessed 11/23/2010.


Other Names for this Disease
  • Galactocerebrosidase deficiency
  • Galactosylceramide beta-galactosidase deficiency
  • GALC deficiency
  • GCL
  • GLD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.