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Genetic and Rare Diseases Information Center (GARD)

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Langerhans cell histiocytosis

Other Names for this Disease
  • Eosinophilic granuloma (formerly)
  • Hand-Schüller-Christian syndrome (formerly)
  • Histiocytosis X
  • LCH
  • Letterer-Siwe disease (formerly)
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What causes Langerhans cell histiocytosis?

The cause of Langerhans cell histiocytosis is unknown.[1][2] It may be triggered by an unusual reaction of the immune system to something commonly found in the environment. It is not considered to be an infection or cancer. It is not known to be hereditary or communicable.[1]
Last updated: 12/2/2013

  1. LCH in Children. Histiocytosis Association of America. 2007; Accessed 2/18/2010.
  2. Shea CR, Boos MD. Langerhans Cell Histiocytosis. eMedicine. 2009; Accessed 2/18/2010.