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Genetic and Rare Diseases Information Center (GARD)

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Langerhans cell histiocytosis

Other Names for this Disease
  • Eosinophilic granuloma (formerly)
  • Hand-Schüller-Christian syndrome (formerly)
  • Histiocytosis X
  • LCH
  • Letterer-Siwe disease (formerly)
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Is Langerhans cell histiocytosis inherited?

Although Langerhans cell histiocytosis is generally considered a sporadic, non-hereditary condition, it has reportedly affected more than one individual in a family in a very limited number of cases (particularly identical twins).[1][2]
Last updated: 12/2/2013

  1. Langerhans Cell Histiocytosis. Online Mendelian Inheritance in Man (OMIM). 2009; Accessed 2/18/2010.
  2. Arico M, Nichols K, Whitlock JA, Arceci R, Haupt R, Mittler U, Kuhne T, Lombardi A, Ishii E, Egeler RM, Danesino C. Br J Haematol. 1999; Accessed 2/18/2010.