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Genetic and Rare Diseases Information Center (GARD)

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Langerhans cell histiocytosis

Other Names for this Disease
  • Eosinophilic granuloma (formerly)
  • Hand-Schüller-Christian syndrome (formerly)
  • Histiocytosis X
  • LCH
  • Letterer-Siwe disease (formerly)
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Tests & Diagnosis

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How is Langerhans cell histiocytosis diagnosed?

Testing for Langerhans cell histiocytosis (LCH) may include bronchoscopy with biopsyx-ray, skin biopsy, bone marrow biopsy, complete blood count, and pulmonary function tests. Because LCH is sometimes associated with cancer, CT scans and a biopsy may be done to rule out possible cancer.[1][2]

Additional information about the diagnosis of LCH can be viewed on the Histiocytosis Association's website.
Last updated: 12/2/2013

  1. Grifo AH. Langerhans Cell Histiocytosis in Children. Association of Pediatric Hematology/Oncology Nurses. 2009;
  2. Satter EK, High WA. Langerhans Cell Histiocytosis: A Review of the Current Recommendations of the Histiocyte Society. Pediatric Dermatology. 2008;