Other Names for this Disease
- Growth hormone insensitivity syndrome
- Growth hormone receptor deficiency
- Laron dwarfism
- Laron type pituitary dwarfism I
- Pituitary dwarfism II
Your QuestionMy grandson has the condition. I want to know if there is medication that will result in a normal stature.
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Treatment for individuals with Laron syndrome mainly aims at improving growth. The only specific treatment available for this condition is subcutaneous injections of insulin-like growth factor 1 (a growth-promoting hormone), often called IGF-1. IGF-1 stimulates linear growth (height) and improves brain growth as well as the metabolic abnormalities caused by long-term IGF-1 deficiency. It has also been shown to raise blood glucose levels, reduce cholesterol, increase muscle growth, and give other benefits. The growth resulting from IGF-1 treatment is less than what is typically seen with human growth hormone (hGH) treatment in children with growth hormone deficiency. Treatment with IGF-1 reportedly stimulates growth by about 8cm in the first year and 4-5cm in the following years, but more studies on the long-term effects on final height are needed. IGF-1 and GH levels should be closely monitored in individuals undergoing this treatment, because overdosage of IGF-I causes a variety of health problems. Infants may also need frequent feedings in order to avoid hypoglycemia.
Last updated: 11/3/2011
- J. Léger. Laron syndrome. Orphanet. November 2009; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=633. Accessed 11/2/2011.
- Zvi Laron. Growth Hormone Insensitivity (Laron Syndrome). Reviews in Endocrine & Metabolic Disorders. 2002; 3:347-355.
- Laron Z. The essential role of IGF-I: lessons from the long-term study and treatment of children and adults with Laron syndrome. J Clin Endocrinol Metab. December 1999; 84(12):4397-4404.
- Laron Z. Insulin-like growth factor-I treatment of children with Laron syndrome (primary growth hormone insensitivity). Pediatr Endocrinol Rev. March 2008; 5(3):766-771.