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Genetic and Rare Diseases Information Center (GARD)

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Other Names for this Disease
  • Congenital laryngeal stridor
  • Congenital laryngomalacia
  • Laryngomalacia congenital
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Is laryngomalacia inherited?

Laryngomalacia may be inherited in some instances. Only a few cases of familial laryngomalacia (occurring in more than one family member) have been described in the literature.[1] In some of these cases, autosomal dominant inheritance has been suggested.[1]

Laryngomalacia has also been reported as being associated with various syndromes.[1] In cases where these specific syndromes are inherited, a predisposition to being born with laryngomalacia may be present. However, even within a family, not all individuals affected with one of these syndromes will have the exact same signs and symptoms (including laryngomalacia). Syndromes that have been associated with laryngomalacia include diastrophic dysplasia, alopecia universalis congenital, XY gonadal dysgenesis, Costello syndrome, DiGeorge syndrome, and acrocallosal syndrome.[1] The inheritance pattern depends upon the specific syndrome present.
Last updated: 10/22/2012

  1. Chen JL, Messner AH, Chang KW. Familial laryngomalacia in two siblings with syndromic features. Int J Pediatr Otorhinolaryngol. September 2006; 70(9):1651-1655.