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Leber hereditary optic neuropathy
Other Names for this Disease
- Leber optic atrophy
- Leber’s disease
- LHON
- Optic atrophy, Leber type
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Overview
Leber hereditary optic neuropathy (LHON) is an inherited form of vision loss. Although this condition usually begins in a person's teens or twenties, rare cases may appear in early childhood or later in adulthood. For unknown reasons, males are affected much more often than females. This condition is caused by mutations in the MT-ND1, MT-ND4, MT-ND4L, and MT-ND6 genes.[1]
References
- Leber hereditary optic neuropathy. Genetics Home Reference (GHR). http://ghr.nlm.nih.gov/condition/leber-hereditary-optic-neuropathy. Accessed December 2, 2011.
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General Information
- Genetics Home Reference (GHR) contains information on Leber hereditary optic neuropathy. Click on the link to go to GHR and review the information.
- The Merck Manuals Online Medical Library provides information on this condition. Click on the link to view the information.
- MeSH® (Medical Subject Headings) is a terminology tool used by the National Library of Medicine. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge. Click on the link to read information on this topic.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Leber hereditary optic neuropathy. Click on the link to view a sample search on this topic.
- The The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Leber hereditary optic neuropathy. Click on the link to go to OMIM and review these resources.