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Ledderhose disease

Other Names for this Disease
  • Lederhose disease
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Ledderhose disease is a type of plantar fibromatosis characterized by thickening of the foot's deep connective tissue.[1] While many individuals with Ledderhose disease do not experience symptoms, over time the condition may progress, causing considerable pain when walking.[1][2] Repeated trauma, long-term alcohol consumption, chronic liver disease, diabetes, and epilepsy have been reported in association with the development of this condition. Heredity is also a clear factor in many patients. Often, patients with Ledderhose disease also have other fibrosing conditions such as Dupuytren contracture, knuckle pads, or Peyronie disease.[1]  The exact prevalence of Ledderhose disease is unknown, with some studies stating it is rare[3], and others stating it is a common condition.[1]
Last updated: 2/24/2011


  1. Hougeir FG, Mascaro JM. Plantar Fibromatosis. eMedicine. July 12, 2010; Accessed 2/17/2011.
  2. Ledderhose's disease. Dupuytren Society. 2011; Accessed 1/28/2011.
  3. De Souza DF, Micaelo, L, Cuzzi T, and Ramos-e-Silva M. Ledderhose Disease: An Unusual Presentation. J Clin Aesthet Dermatol. 2010; 3:45-47. Accessed 2/17/2011.
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