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Genetic and Rare Diseases Information Center (GARD)

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Ledderhose disease

Other Names for this Disease
  • Lederhose disease
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Your Question

I have Ledderhose disease and Dupuytren's contracture. I also have a family history of these conditions. My condition has worsened despite multiple surgeries. Is there a satisfactory treatment for Ledderhose?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

How might Ledderhose disease be treated?

There is little evidence regarding the effectiveness of specific treatment approaches for Ledderhose disease. Initial treatment approach may invovle regular (monthly or less often) glucocorticoid injection and soft shoe inserts with cutouts for the nodules.[1] Surgery, such as selective fasciectomy or dermofasciectomy, has been used as treatment of people who do not respond to initial therapy. Recurrence following surgery is common.[1] Collagenase injection is an additional therapy which has been used with variable sucess.[2][3]

Our search identified one case report describing the use of "upper lateral arm flaps" on the feet of two brother's who had multiple recurrences following other procedures.[4] The reference for this article is provided below.

Kan HJ, Hovius SE. Long-term follow-up of flaps for extensive Dupuytren's and Ledderhose disease in one familyJ Plast Reconstr Aesthet Surg. 2012 December;65(12):1741-5.

The International Dupyytren Society provides futher information on treatment options for Ledderhose disease at the following link:

We strongly recommend that you review this information with your healthcare providers. Only a healthcare provider can help you make decisions regarding which treatment approach may be best for you.
Last updated: 7/1/2013

  • Sheon RP, De Keyser F. Ganglia and nodules. In: Basow DS. UpToDate. Waltham, MA: UpToDate; 2013;
  • van Rijssen AL Werker PM. Treatment of Dupuytren's contracture; an overview of options. Ned Tijdschr Geneeskd. 2009;153:A129; Accessed 6/28/2013.
  • Therapies for Ledderhose's disease (Plantar fibromatosis or Morbus Ledderhose) . International Dupuytren Society. March 29, 2013; Accessed 7/1/2013.
  • Kan HJ, Hovius SE. Long-term follow-up of flaps for extensive Dupuytren's and Ledderhose disease in one family. J Plast Reconstr Aesthet Surg. 2012 Dec;65(12):1741-5; Accessed 6/28/2013.
  • Watt AJ, Curtin CM, Hentz VR. Collagenase injection as nonsurgical treatment of Dupuytren's disease: 8-year follow-up. J Hand Surg Am. 2010 Apr;35(4):534-9, 539.e1; Accessed 6/28/2013.