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Other Names for this Disease
- Sarcoma family syndrome of Li and Fraumeni
- SBLA syndrome (Sarcoma, Breast, Leukemia, and Adrenal Gland)
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Your QuestionIf my father had a TP53 mutation, does that mean all his children have the mutation or each has a 50% chance of having it? If my father had the mutation and I do not have it, do my own children have a chance of having it or are they and all successive generations in the clear? If my family clearly meets the criteria for diagnosing this condition, but no one demonstrates the TP53 mutation in genetic testing, is it possible to determine if a given relative never diagnosed with cancer has the predisposition?
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If a parent has Li Fraumeni syndrome and the diagnosis is confirmed by the finding of a mutation in the TP53 gene, each of his/her children has a 50% chance to inherit the TP53 mutation and have this condition. Whether or not one child inherits the TP53 mutation does not affect the chance that the next child could inherit it; each child has a 50% chance. If the child of a person with Li Fraumeni syndrome has not inherited the TP53 mutation previously identified in their parent, they do not have Li Fraumeni syndrome and they cannot pass this condition on to their own children or any of their descendants.
Last updated: 5/4/2012
If a family history of cancer meets criteria for Li Fraumeni syndrome but no TP53 mutation is found on genetic testing, there is no way to know with certainty which relatives may have inherited the predisposition to develop cancer. If full testing of the TP53 gene is completed (including sequence analysis of the entire gene and testing for missing or extra portions within the gene), a mutation will be identified in 90% of families that meet criteria; however, this means that no mutation will be found in 10% of families that meet criteria. If no TP53 mutation is identified but the family history is suggestive of Li Fraumeni syndrome, the National Comprehensive Cancer Network (NCCN) considers cancer-free family members to be at risk for having a predisposition to cancer, and these relatives are recommended to pursue careful cancer screening based on the family history of cancer. In a family that meets criteria for Li Fraumeni but lacks an identified TP53 mutation, those relatives who live to their 50s and 60s without developing cancer are unlikely to have inherited the predisposition to cancer, because the chance of developing cancer in this condition are quite high at young ages.
Last updated: 5/4/2012
- Schneider K and Garber J. Li-Fraumeni Syndrome . GeneReviews. February 2010;
- National Comprehensive Cancer Network. Genetic/Familial High-Risk Assessment: Breast and Ovarian. NCCN Guidelines in Clinical Oncology . May 2012; http://www.nccn.org/professionals/physician_gls/pdf/genetics_screening.pdf. Accessed 5/4/2012.