Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Other Names for this Disease
  • LFS1
  • Sarcoma family syndrome of Li and Fraumeni
  • SBLA syndrome (Sarcoma, Breast, Leukemia, and Adrenal Gland)
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Inheritance


Newline Maker

How is Li-Fraumeni syndrome inherited?

Li-Fraumeni syndrome is inherited in an autosomal dominant manner. This means that only one mutated copy of the disease-causing gene in each cell is sufficient to increase the risk of developing cancer. The mutated gene may be inherited from an affected parent or may occur for the first time in the affected individual (a de novo mutation). The proportion of individuals with a de novo mutation is unknown.[1] To our knowledge there is no evidence that environmental exposures increase a person's risk to be born with Li-Fraumeni syndrome.

Each child of an individual with an autosomal dominant condition has a 50% (1 in 2) chance to inherit the mutated gene. If the child of an affected parent does not inherit the mutated gene, that child cannot pass the mutated gene on to offspring.
Last updated: 8/8/2012

References
  1. Schneider K, Garber J. Li-Fraumeni syndrome. GeneReviews. February 9, 2010; http://www.ncbi.nlm.nih.gov/books/NBK1311/. Accessed 8/8/2012.