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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Loin pain hematuria syndrome


Other Names for this Disease
  • LPHS
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Cause

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What causes loin pain hematuria syndrome?

The exact underlying cause of loin pain hematuria syndrome (LPHS) is currently unknown. However, scientists have proposed several theories. For example, some cases of LPHS may be due to abnormal glomerular basement membranes, which are the tissues in the kidney that filter blood. If these tissues are abnormal, red blood cells may be allowed to enter the urinary space, leading to both loin pain and hematuria (blood in the urine). Other factors that may lead to the signs and symptoms of LPHS include:[1][2]
  • Blood disorders, called coagulopathies, which impair the bloods ability to clot
  • Spasms in the kidney's blood vessels which may restrict blood flow to certain tissues and lead to tissue death
Up to 50% of people affected by LPHS also experience kidney stones. Some scientists, therefore, suspect that the formation of crystals and/or stones in the kidney may also contribute to the condition as they may block or injure the renal tubules (the long narrow tubes in the kidney that concentrate and transport urine).[1][2]
Last updated: 4/1/2015

References
  1. Taba Taba Vakili S, Alam T, Sollinger H. Loin pain hematuria syndrome. Am J Kidney Dis. September 2014; 64(3):460-472.
  2. Lee A Hebert, MD; Costantino Benedetti, MD; Samir V Parikh, MD; Tibor Nadasdy, MD. Loin pain-hematuria syndrome. UptoDate. May 2014; Accessed 4/1/2015.


Other Names for this Disease
  • LPHS
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.