Marchiafava Bignami disease
Other Names for this Disease
- Acute Marchiafava-Bignami disease
- Chronic Marchiafava-Bignami syndrome
demyelination of the corpus callosum (erosion of the protective covering of nerve fibers joining the 2 hemispheres of the brain). The disease seems to most often affect severe and chronic alcoholics in their middle or late adult life. Early symptoms may include depression, paranoia, psychosis, or dementia. Seizures are common, and hemiparesis, aphasia, abnormal movements, and ataxia may sometimes progress to coma and/or death. The cause of Marchiafava Bignami disease, including the potential role of nutritional deficiency, is unknown. Improvement and recovery of some individuals has been reported. Treatment focuses on nutritional support and rehabilitation from alcoholism.Marchiafava Bignami disease is defined by characteristic
Last updated: 6/1/2011
On this page
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Marchiafava Bignami disease. Click on the link to view a sample search on this topic.