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Genetic and Rare Diseases Information Center (GARD)

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Marchiafava Bignami disease

Other Names for this Disease
  • Acute Marchiafava-Bignami disease
  • Chronic Marchiafava-Bignami syndrome
  • MBD
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How might Marchiafava Bignami disease be treated?

In individuals who have recovered from Marchiafava Bignami disease (MBD), it is not clear whether improvement was a result of vitamin supplementation or merely a reflection of the disease's natural history.[1] Treatment should generally focus on nutritional support and rehabilitation from alcoholism (when alcoholism is present).[1] Various treatments, including those typically used for alcoholism in general, have been given to patients with MBD. Some have improved and some have not. The most common treatments are thiamine and other B vitamins (especially vitamin B-12 and folate, which is not a B vitamin but is commonly given with B-12). No specific proven treatment is available.[2] It has been recommended that individuals who survive the disease receive rehabilitation and, if appropriate, alcohol and nutritional counseling.[2]
Last updated: 6/1/2011

  1. Walter G. Bradley et al. Neurology in Clinical Practice, 5th ed.. USA: Butterworth-Heinemann; 2008 ;
  2. Jennifer Ault. Marchiafava-Bignami Disease. eMedicine. February 3, 2010; Accessed 5/31/2011.