Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Marcus Gunn phenomenon


Other Names for this Disease

  • Familial Marcus Gunn phenomenon (subtype)
  • Jaw-winking
  • Marcus Gunn syndrome
  • Maxillopalpebral synkinesis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Marcus Gunn phenomenon is a rare condition characterized by movement of the upper eyelid in a rapid rising motion (a "wink") each time the jaw moves.[1] The wink phenomenon may be elicited by opening the mouth, thrusting the jaw to the side, jaw protrusion, chewing, smiling, or sucking.[2] It is usually present at birth and may occur with other eye abnormalities (such as strabismus) or vision problems.[1][[2] Although it is usually unilateral, it can affect both eyes in rare cases.[2] The exact cause is not known. Marcus Gunn phenomenon is generally sporadic, but familial cases with autosomal dominant inheritance have been reported.[3][2] Treatment is not always needed but may include surgery in more severe cases.[4]
Last updated: 3/6/2013

References

  1. Marcus Gunn Phenomenon. National Organization for Rare Disorders (NORD). 2003; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Marcus%20Gunn%20Phenomenon. Accessed 7/1/2009.
  2. Sean M Blaydon. Marcus Gunn Jaw-winking Syndrome. Medscape Reference. November 16, 2011; http://emedicine.medscape.com/article/1213228-overview. Accessed 3/5/2013.
  3. Marcus-Gunn syndrome. Orphanet. April 2007; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=91412. Accessed 3/4/2013.
  4. Marcus Gunn Phenomenon. Marcus Gunn Phenomenon. March 24, 2008; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/833/viewAbstract. Accessed 3/6/2013.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

1 question(s) from the public on Marcus Gunn phenomenon have been answered. See questions and answers. You can also submit a new question.

Basic Information

  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Marcus Gunn phenomenon. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Familial Marcus Gunn phenomenon (subtype)
  • Jaw-winking
  • Marcus Gunn syndrome
  • Maxillopalpebral synkinesis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.