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Diseases

Genetic and Rare Diseases Information Center (GARD)

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McCune Albright syndrome

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Other Names for this Disease

  • Albright syndrome
  • Albright's disease
  • MAS
  • PFD
  • POFD
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Inheritance

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Is McCune Albright syndrome inherited?

McCune Albright syndrome (MAS) is not inherited. It is caused by a random change (mutation) in the GNAS gene that occurs very early in development. As a result, some of the body's cells have a normal version of the GNAS gene, while other cells have the mutated version. This phenomenon is called mosaicism.[1][2] The severity of this disorder and its specific features depend on the number and location of cells that have the mutated GNAS gene.[1] This mutation is not passed on to any of the affected individual's children.[2]
Last updated: 12/26/2013

References
  1. McCune-Albright syndrome. Genetics Home Reference (GHR). January 2009; http://ghr.nlm.nih.gov/condition=mccunealbrightsyndrome. Accessed 10/17/2013.
  2. Haldeman-Englert C. McCune-Albright syndrome. MedlinePlus. 2012; http://www.nlm.nih.gov/medlineplus/ency/article/001217.htm. Accessed 10/17/2013.


Other Names for this Disease
  • Albright syndrome
  • Albright's disease
  • MAS
  • PFD
  • POFD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.