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Genetic and Rare Diseases Information Center (GARD)

Other Names for this Disease
  • Albright syndrome
  • Albright's disease
  • MAS
  • PFD
  • POFD
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How might McCune Albright syndrome be treated?

Although there is no cure for McCune Albright syndrome (MAS), drug treatments may help some of the endocrine symptoms, and surgery can help repair some of the bone problems.[1] Generally, treatment depends on what tissues are affected as well as the severity.[2]

Surgery may be needed to manage complications associated with fibrous dysplasia, such as progressive visual disturbance, severe pain, and severe disfigurement. Surgery may also be needed to manage associated endocrine abnormalities and/or cancers. Bisphosphonates are frequently used to treat fibrous dysplasia. Strengthening exercises are recommended to help maintain musculature around the bones and minimize the risk of fracture. Treatment of all endocrine symptoms, whether by hormone inhibitors or surgery, is commonly required.[3][2]

More detailed information about the management of MAS syndrome is available on Medscape Reference's Web site.
Last updated: 1/2/2014

  1. McCune-Albright Syndrome. National Institute of Child Health and Human Development (NICHD). 2013; Accessed 10/17/2013.
  2. Dumitrescu CE, Collins MT. McCune-Albright syndrome. Orphanet. 2008; Accessed 7/20/2009.
  3. Haldeman-Englert C. McCune-Albright syndrome. MedlinePlus. 2012; Accessed 10/17/2013.

Clinical Trials & Research for this Disease

  • lists trials that are studying or have studied McCune Albright syndrome. Click on the link to go to to read descriptions of these studies.