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Microvillus inclusion disease

Other Names for this Disease
  • Congenital familial protracted diarrhea
  • Congenital familial protracted diarrhea with enterocyte brush-border abnormalities
  • Congenital microvillous atrophy
  • Davidson disease
  • Davidson's disease
More Names
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Microvillus inclusion disease is an intestinal disorder characterized by severe, watery diarrhea and an inability of the intestines to absorb nutrients. Symptoms typically develop in the first days (early-onset) or first months (late-onset) of life. Without adequate water and nutrients, children with this condition can become dehydrated, suffer from malnutrition, and fail to grow and develop normally. Management is difficult and relies on total parenteral nutrition. The advent of intestinal transplantation has improved the outlook for these patients. Microvillus inclusion disease is inherited in an autosomal recessive manner.[1][2]
Last updated: 10/5/2011


  1. Microvillus Inclusion Disease. Children's Hospital of Pittsburgh. December 12, 2010; Accessed 10/5/2011.
  2. Ruemmele FM, Schmitz J, Goulet O. Microvillous inclusion disease. Orphanet. June 2006; Accessed 10/5/2011.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Microvillus inclusion disease. This website is maintained by the National Library of Medicine.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Microvillus inclusion disease. Click on the link to view a sample search on this topic.

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