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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Mixed connective tissue disease


Other Names for this Disease
  • MCTD
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Your Question

What causes mixed connective tissue disease? Is it genetic? Is it due to environmental exposures?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What causes mixed connective tissue disease?

The exact underlying cause of mixed connective tissue disease (MCTD) is currently unknown. It is an autoimmune disorder, which means the immune system mistakes normal, healthy cells for those that that body should "fight off." There are ongoing studies exploring how immune system dysfunction may be involved in the development of this condition.[1][2]
Last updated: 12/29/2014

Is mixed connective tissue disease inherited?

The role of genetics in the onset of mixed connective tissue disease (MCTD) is still unclear. Some people with MCTD have family members who are also affected by the condition. This suggests that in some cases, an inherited predisposition may contribute to the development of MCTD. People with an inherited or genetic predisposition have an increased risk of developing a certain condition due to their genes.[2][3]
Last updated: 12/29/2014

References
Other Names for this Disease
  • MCTD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.