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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Mixed connective tissue disease


Other Names for this Disease
  • MCTD
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Prognosis

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What is the long-term outlook for people with mixed connective tissue disease?

In general, the long-term outlook (prognosis) for people with mixed connective tissue disease (MCTD) is favorable, but it mostly depends on the signs and symptoms present in each person.[1][2]

The overall 10-year survival rate of the disease is about 80%.[1] Some people have symptom-free periods lasting for many years with no treatment. Despite treatment, the disease gets worse in about 13% of people and can cause potentially fatal complications in six to 12 years.[3] The prognosis is worse for people with features of systemic sclerosis and/or polymyositis. Pulmonary hypertension is the most common MCTD-associated cause of death.[1]
Last updated: 12/30/2014

References
  1. Zahir Amoura and Laurent Arnaud. Mixed connective tissue disease. Orphanet. October, 2009; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=809.
  2. Eric L Greidinger, MD. Mixed Connective-Tissue Disease. Medscape Reference. February 2013; http://emedicine.medscape.com/article/335815-overview.
  3. Rula A. Hajj-ali. Mixed Connective Tissue Disease (MCTD). Merck Manuals. August, 2013; http://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/mixed_connective_tissue_disease_mctd.html?qt=&sc=&alt=#top.


Other Names for this Disease
  • MCTD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.