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Genetic and Rare Diseases Information Center (GARD)

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Muenke Syndrome

Other Names for this Disease
  • Muenke nonsyndromic coronal craniosynostosis
  • Syndrome of coronal craniosynostosis
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What causes Muenke syndrome?

Muenke syndrome is caused by mutations in the FGFR3 gene. This gene provides instructions for making a protein that is involved in the development and maintenance of bone and brain tissue. A single mutation in the FGFR3 gene causes the FGFR3 protein to be overly active, which interferes with normal bone growth and allows the bones of the skull to fuse before they should.[1]
Last updated: 10/3/2011

  1. Muenke syndrome. Genetics Home Reference (GHR). June 2006; Accessed 10/3/2011.