Other Names for this Disease
- Giant cell histiocytomatosis
- Lipoid dermatoarthritis
What are the symptoms of multicentric reticulohistiocytosis?
How might multicentric reticulohistiocytosis be treated?
What is the prognosis for individuals with multicentric reticulohistiocytosis?
The clinical presentation of multicentric reticulohistiocytosis is insidious in onset and begins with arthritic complaints in approximately two thirds of patients. It is potentially one of the most rapidly destructive forms of arthritis. Joint involvement remits and relapses, gradually worsening into a debilitating and permanent arthritis multilans. The severity of the damage has been reported to be related to the age of onset; therefore, the earlier one has symptoms, the more severe the symptoms tend to be. Like the associated arthritis, skin lesions tend to wax and wane until the disease spontaneously resolves, but may leave permanent disfigurement.
- Chakravarty EF, Genovese MC. Chapter 111 -- Musculoskeletal Syndromes in Malignancy. Harris: Kelley’s Textbook of Rheumatology, 7th ed.. Philadelphia, PA: W.B. Saunders Company; 2005;
- West SG. Chapter 297 -- Systemic Diseases in Which Arthritis is a Feature. Goldman: Cecil Textbook of Medicine, 23rd ed.. Philadelphia, PA: Saunders Elsevier; 2008;
- Rapini RP, Morgan LT. Dermatologic Manifestations of Multicentric Reticulohistiocytosis . Medscape Reference . June 6, 2012; http://emedicine.medscape.com/article/1058248-overview. Accessed 9/28/2012.
- Hsiung et al.. Multicentric reticulohistiocytosis presenting with clinical features of dermatomyositis. Journal of the American Academy of Dermatology. 2003;
- Callen JP. Multicentric Reticulohistiocytosis. Medscape Reference. August 16, 2011; http://emedicine.medscape.com/article/283885-overview. Accessed 9/28/2012.