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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Multiple myeloma


Other Names for this Disease

  • Kahler disease
  • Myeloma - multiple
  • Myelomatosis
  • Plasma cell dyscrasia
  • Plasma cell myeloma
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Symptoms

Newline Maker

What are the signs and symptoms of multiple myeloma?

Multiple myeloma causes anemia, which makes a person more likely to get infections and have abnormal bleeding. As the cancer cells grow in the bone marrow, bone or back pain can occur, most often in the ribs or back. If the bones in the spine are affected, it can put pressure on the nerves, resulting in numbness or weakness of the arms or legs. Other symptoms include:[1][2]

  • Bleeding problems
  • Fatigue and weakness due to anemia
  • Frequent infections and fevers without any other cause
  • Shortness of breath due to anemia
  • Unexplained broken bones
  • Weight loss
  • Nausea or constipation
Last updated: 7/6/2011

The Human Phenotype Ontology provides the following list of signs and symptoms for Multiple myeloma. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Abnormality of metabolism/homeostasis -
Autosomal recessive inheritance -
Multiple myeloma -
Somatic mutation -

Last updated: 12/1/2014

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. What You Need To Know About Multiple Myeloma. National Cancer Institute. November 20, 2008; http://www.cancer.gov/cancertopics/wyntk/myeloma. Accessed 7/6/2011.
  2. Multiple Myeloma. MedlinePlus. February 2011; http://www.nlm.nih.gov/medlineplus/ency/article/000583.htm. Accessed 7/6/2011.


Other Names for this Disease
  • Kahler disease
  • Myeloma - multiple
  • Myelomatosis
  • Plasma cell dyscrasia
  • Plasma cell myeloma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.