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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Mycobacterium Avium Complex


Other Names for this Disease

  • MAC
  • MAI
  • Mycobacterium Avium
  • Mycobacterium Avium-Intracellulare
  • Mycobacterium Avium-Intracellulare infection
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Treatment

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How might mycobacterium avium complex be treated?

Mycobacterium avium complex is associated with several different conditions including pulmonary MAC, which affects the lungs; disseminated MAC, which affects many different parts of the body; and MAC lymphadenitis, which causes swollen lymph nodes. The best treatment options vary by condition. Pulmonary MAC and disseminated MAC are usually treated with a combination of antibiotics and/or antituberculosis medications. Care must be taken in choosing the appropriate combination of medications as some of the disease-causing bacteria can be resistant to many types of antibiotics and antituberculosis drugs. Surgical treatment may be considered in people with a poor response to drug therapy, drug-resistant MAC or the presence of many condition-related complications if the infection only affects one lung and the procedure is thought to be well-tolerated.[1][2]

Treatment of MAC lymphadenitis usually involves surgical removal of affected lymph nodes. Affected people may also be prescribed antibiotics depending on the severity of condition and their response to surgery.[1][2]
Last updated: 12/14/2014

References
  1. Janak Koirala, MD, MPH, FACP, FIDSA. Mycobacterium Avium-Intracellulare. Medscape Reference. March 2014; http://emedicine.medscape.com/article/222664-overview.
  2. David E. Griffith, Timothy Aksamit, Barbara A. Brown-Elliott, Antonino Catanzaro, Charles Daley, Fred Gordin, Steven M. Holland, Robert Horsburgh, Gwen Huitt, Michael F. Iademarco, Michael Iseman, Kenneth Olivier, Stephen Ruoss, C. Fordham von Reyn, Richard J. Wallace, Jr., and Kevin Winthrop. An Official ATS/IDSA Statement: Diagnosis, Treatment, and Prevention of Nontuberculous Mycobacterial Diseases. American Journal of Respiratory and Critical Care Medicine. 2007; 175(4):367-416.


Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Mycobacterium Avium Complex. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • MAC
  • MAI
  • Mycobacterium Avium
  • Mycobacterium Avium-Intracellulare
  • Mycobacterium Avium-Intracellulare infection
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.