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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Nail patella syndrome


Other Names for this Disease

  • Arthro-Onychodysplasia
  • Fong disease
  • NPS 1
  • Onychoosteodysplasia
  • Osteo-Onychodysplasia
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Your Question

I have nail patella syndrome. Can you tell me if the risk for pre-eclampsia in pregnancy is increased significantly for a woman over the age of 35? This will be my second pregnancy and I did not have any issues with my first child except for a minimal amount of proteinuria at 20 weeks.

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Can you tell me if the risk for pre-eclampsia in pregancy is increased significantly for a woman over the age of 35?

Although age is one of the risk factors for developing pre-eclampsia, it appears that the risk of pre-eclampsia is higher for pregnant women younger than 20 and older than 40.[1] If you are over 40, you are nearly twice as likely to develop pre-eclampsia as a woman under 40.[2]
Last updated: 9/14/2010

Are women with nail patella syndrome at an increased risk to develop pre-eclampsia?

Yes. In pregnancy, women with nail patella syndrome face an increased frequency of pre-eclampsia.[3] Pregnancy can accelerate the clinical onset of a pre-existent glomerulopathy and also aggravate proteinuria. This should be considered when dealing with pregnant nail patella syndrome patients, whether or not they have a diagnosed nephropathy.[4] Such pregnancies may be regarded as high risk and should be managed appropriately.[5] 
Last updated: 9/14/2010

References
Other Names for this Disease
  • Arthro-Onychodysplasia
  • Fong disease
  • NPS 1
  • Onychoosteodysplasia
  • Osteo-Onychodysplasia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.