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Nevoid basal cell carcinoma syndrome
Other Names for this Disease
- Basal Cell Nevus Syndrome
- Fifth Phacomatosis
- Gorlin Syndrome
- Gorlin-Goltz Syndrome
- Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies
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Nevoid basal cell carcinoma syndrome is a type of genetic tumor syndrome. Signs and symptoms include an increased risk for certain types of noncancerous and cancerous tumors, skin pits in the palms of the hands and soles of the feet, large head size, and bone abnormalities involving the spine, ribs, or skull. Nevoid basal cell carcinoma syndrome is caused by a mutation in the gene PTCH1. It is inherited in an autosomal dominant fashion.
- Gorlin syndrome. Genetic Home Reference. http://ghr.nlm.nih.gov/condition/gorlin-syndrome. Accessed June 23, 2010.
- Sparks SE, Krasnewich DM. Nevoid Basal Cell Carcinoma. GeneReviews. http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=bcns. Accessed July 23, 2010.
- DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition. Click on the link to view the information.
- Genetics Home Reference (GHR) contains information on Nevoid basal cell carcinoma syndrome. Click on the link to go to GHR and review the information.
- MedlinePlus, a Web site designed by the National Library of Medicine to help you research your health questions, provides more information about this topic. Click on the link to view this information.
- MeSH® (Medical Subject Headings) is a terminology tool used by the National Library of Medicine. Click on the link to view information on this topic.
- The National Cancer Institute (CIS) provides the most current information on cancer for patients, health professionals, and the general public. You can reach them by calling toll-free at 1-800-422-6237 or by visiting their Web site.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
- eMedicine has two articles on this topic from the perspective of pediatric oncology and dermatology. You may need to register to view the information online, but registration is free. Click on the links above to view the articles from this medical reference Web site.
- The American Society of Clinical Oncology has developed an information page on nevoid basal cell carcinoma syndrome. Click on the link above to view the information page
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge. Click on the link to read information on this topic.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Nevoid basal cell carcinoma syndrome. Click on the link to view a sample search on this topic.
- The The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Nevoid basal cell carcinoma syndrome. Click on the link to go to OMIM and review these resources.
Selected Full-Text Journal Articles
- Muzio LL. Nevoid basal cell carcinoma syndrome (Gorlin syndrome). Orphanet Journal of Rare Diseases. 2008;3:32