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Genetic and Rare Diseases Information Center (GARD)

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Nephrogenic diabetes insipidus

Other Names for this Disease
  • ADH resistant diabetes insipidus
  • Diabetes insipidus nephrogenic
  • Diabetes insipidus nephrogenic type 1
  • Diabetes insipidus nephrogenic X-linked
  • Vasopressin-resistant diabetes insipidus
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  • My 14 year old son was diagnosed with nephrogenic diabetes insipidus 7 years ago. He has been taking indomethacin and hydrochlorothiazide and his urine output is fairly well controlled. Recently he developed gout in his big toe. His rheumatologist thinks that it may be due to the thiazide so he was switched to amiloride. Unfortunately, his symptoms got worse so he was put back on indomethacin and hydrochlorothiazide. What causes this condition? How is it inherited? How it it diagnosed? What treatments are available? Will he need to take medication for the rest of his life? Click here for answer