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Genetic and Rare Diseases Information Center (GARD)

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Nephrogenic diabetes insipidus


Other Names for this Disease

  • ADH resistant diabetes insipidus
  • Diabetes insipidus nephrogenic
  • Diabetes insipidus nephrogenic type 1
  • Diabetes insipidus nephrogenic X-linked
  • Vasopressin-resistant diabetes insipidus
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Overview

Nephrogenic diabetes insipidus is a disorder in which a defect in the small tubes (tubules) in the kidneys causes a person to pass a large amount of urine. Nephrogenic diabetes insipidus occurs when the kidney tubules, which allow water to be removed from the body or reabsorbed, do not respond to a chemical in the body called antidiuretic hormone (ADH) or vasopressin. ADH normally tells the kidneys to make the urine more concentrated. As a result of the defect, the kidneys release an excessive amount of water into the urine, producing a large quantity of very dilute urine.[1]

Nephrogenic diabetes insipidus can be either acquired or hereditary. The acquired form is brought on by certain drugs and chronic diseases and can occur at any time during life. The hereditary form is caused by genetic mutations, and its signs and symptoms usually become apparent within the first few months of life.[2]
Last updated: 7/31/2011

References

  1. Diabetes insipidus - nephrogenic. Medlineplus. June 2010; http://www.nlm.nih.gov/medlineplus/ency/article/000511.htm. Accessed 7/31/2011.
  2. Nephrogenic diabetes insipidus. Genetics Home Reference. April 2010; http://ghr.nlm.nih.gov/condition/nephrogenic-diabetes-insipidus. Accessed 7/31/2011.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Nephrogenic diabetes insipidus. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers. 
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • MeSH® (Medical Subject Headings) is a terminology tool used by the National Library of Medicine. Click on the link to view information on this topic.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Nephrogenic diabetes insipidus. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • ADH resistant diabetes insipidus
  • Diabetes insipidus nephrogenic
  • Diabetes insipidus nephrogenic type 1
  • Diabetes insipidus nephrogenic X-linked
  • Vasopressin-resistant diabetes insipidus
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.