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Nephrogenic diabetes insipidus
Other Names for this Disease
- ADH resistant diabetes insipidus
- Diabetes insipidus nephrogenic
- Diabetes insipidus nephrogenic type 1
- Diabetes insipidus nephrogenic X-linked
- Vasopressin-resistant diabetes insipidus
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Overview
Nephrogenic diabetes insipidus is a disorder in which a defect in the small tubes (tubules) in the kidneys causes a person to pass a large amount of urine. Nephrogenic diabetes insipidus occurs when the kidney tubules, which allow water to be removed from the body or reabsorbed, do not respond to a chemical in the body called antidiuretic hormone (ADH) or vasopressin. ADH normally tells the kidneys to make the urine more concentrated. As a result of the defect, the kidneys release an excessive amount of water into the urine, producing a large quantity of very dilute urine.[1]
Nephrogenic diabetes insipidus can be either acquired or hereditary. The acquired form is brought on by certain drugs and chronic diseases and can occur at any time during life. The hereditary form is caused by genetic mutations, and its signs and symptoms usually become apparent within the first few months of life.[2]
Nephrogenic diabetes insipidus can be either acquired or hereditary. The acquired form is brought on by certain drugs and chronic diseases and can occur at any time during life. The hereditary form is caused by genetic mutations, and its signs and symptoms usually become apparent within the first few months of life.[2]
References
- Diabetes insipidus - nephrogenic. Medlineplus. http://www.nlm.nih.gov/medlineplus/ency/article/000511.htm. Accessed July 31, 2011.
- Nephrogenic diabetes insipidus. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/nephrogenic-diabetes-insipidus. Accessed July 31, 2011.
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General Information
- Genetics Home Reference (GHR) contains information on Nephrogenic diabetes insipidus. Click on the link to go to GHR and review the information.
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- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge. Click on the link to read information on this topic.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Nephrogenic diabetes insipidus. Click on the link to view a sample search on this topic.
- The The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Nephrogenic diabetes insipidus. Click on the link to go to OMIM and review these resources.