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Other Names for this Disease
- Melanosis, neurocutaneous
- Neurocutaneous melanosis syndrome
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central nervous system. It is characterized by melanocytic nevi in both the skin and the brain. Two-thirds of people with NCM have giant congenital melanocytic nevi, and the remaining one-third have numerous lesions but no giant lesions. Most patients present with neurological features early in life, which can be secondary to intracranial hemorrhages (bleeding in the brain), impairment of cerebrospinal fluid circulation (fluid around the brain and spinal cord), and/or malignant transformation of the melanocytes.Neurocutaneous melanosis (NCM) is a rare, non-inherited condition of the
The prognosis of patients with symptomatic neurocutaneous melanosis is extremely poor, even in the absence of malignancy. Chemotherapy has been ineffective in the few patients in whom it has been tried.
Last updated: 4/18/2011
- Di Rocco F, Sabatino G et al. Neurocutaneous melanosis. Childs Nerv Syst. 2004; http://www.ncbi.nlm.nih.gov/pubmed/14576958. Accessed 4/18/2011.
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- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Neurocutaneous melanosis. Click on the link to go to OMIM and review these resources.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Neurocutaneous melanosis. Click on the link to view a sample search on this topic.