- Multiple cartilaginous enchondroses
- Multiple enchondromatosis
Your QuestionAs an individual with Ollier disease, I have had difficulty locating information regarding the prognosis of this condition. What are the symptoms? What are the chances of developing cancer or malignant growths? What type of follow-up do I need as I age?
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Questions on this page
- What is Ollier disease?
- What are the symptoms of Ollier disease?
- What causes Ollier disease?
- What are the chances that the benign tumors found in Ollier disease will become malignant (cancerous)?
- How might Ollier disease be treated?
- What type of follow-up should individuals with Ollier disease have as they age?
- What is the prognosis for individuals with Ollier disease?
Research has shown that patients with numerous lesions may have a better prognosis than patients with localized cartilaginous changes, which may induce major shortening of a lower extremity and thus limb asymmetry. Similarly, early development of enchondromas in phalanges may lead to major finger deformities. As is generally the case, forms with an early onset appear more severe. After puberty, the enchondromas typically stabilize as cartilage is replaced by bone.
The most significant factors regarding prognosis in Ollier disease are related to the complications, most notably pathologic fracture and a small incidence of malignant transformation.
- Ollier Disease. National Organization for Rare Disorders (NORD). 2006; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/337/viewAbstract. Accessed 5/19/2011.
- Chew FS, Maldjian C. Enchondroma and Enchondromatosis. eMedicine. 2009; http://emedicine.medscape.com/article/389224-overview. Accessed 5/19/2011.
- Silve C, Juppner H. Ollier disease. Orphanet Journal of Rare Diseases. 2006; http://www.ojrd.com/content/1/1/37. Accessed 5/19/2011.
- Enchondromatosis, Multiple. Online Mendelian Inheritance in Man (OMIM). 2005; http://www.ncbi.nlm.nih.gov/omim/166000. Accessed 5/19/2011.
- Gibbons CLMH. Ollier Disease. NORD Guide to Rare Diseases. Philadelphia, PA: Lippincott Williams & Wilkins; 2003;