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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Ovarian carcinosarcoma


Other Names for this Disease
  • Malignant mixed mullerian tumor of the ovary
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Treatment


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How might ovarian carcinosarcoma be treated?

Because ovarian carcinosarcoma is rare, there are no established treatment guidelines.  Treatment decisions are based on the unique features of each individual's diagnosis.[1]  The National Comprehensive Cancer Network (NCCN), a group of physicians and researchers who strive to improve cancer care, recommends that women with ovarian carcinosarcoma be treated similarly to women with ovarian carcinoma (also called epithelial ovarian cancer), which is the most common type of ovarian cancer.[2]

Currently, treatment for ovarian carcinosarcoma usually begins with surgery to remove as much of the cancer as possible.  Chemotherapy may be used to destroy any cancer cells that could be in the body after surgery.  Medications that contain platinum (such as the drug cisplatin) seem to be the most effective chemotherapies for ovarian carcinosarcoma.  Recent evidence suggests that another medication called ifosfamide may increase the effectiveness of treatment when used in combination with platinum-based medications.[1]
Last updated: 9/4/2012

References
  1. del Carmen MG, Birrer M, Schorge JO. Carcinosarcoma of the ovary: a review of the literature. Gynecologic Oncology. 2012; 125:271-277. http://www.ncbi.nlm.nih.gov/pubmed/22155675. Accessed 8/31/2012.
  2. National Comprehensive Cancer Network. Ovarian Cancer. NCCN Guidelines for Patients. 2010; http://www.nccn.com/files/cancer-guidelines/ovarian/index.html. Accessed 9/4/2012.


Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Ovarian carcinosarcoma. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.