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Other Names for this Disease
- Broad gyri of cerebrum
- Large gyri of cerebrum
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Pachygyria is a rare developmental disorder which results from abnormal migration of neurons in the developing brain and nervous system. In pachygyria, the gyri are relatively few and are unusually broad and flat. The condition does not affect the entire brain, and is also known as ‘incomplete lissencephaly.’ Symptoms are variable, but may include seizures, developmental delay, growth failure, small head size, feeding issues and poor muscle control. Most cases are isolated, although autosomal dominant and recessive forms have been described. Treatment is symptomatic and supportive.
Last updated: 8/18/2009
- NINDS Neuronal Migration Disorders Information Page. National Institute of Neurological Disorders and Stroke (NINDS) Web site. 2007; http://www.ninds.nih.gov/health_and_medical/disorders/neuronal_migration.htm. Accessed 8/18/2009.
- Grainger & Allison's Diagnostic Radiology: A Textbook of Medical Imaging, 4th ed.. 2001;
- Straussberg R, Gross S, Amir J, Gadoth N. Clin Genet. 1996; http://www.ncbi.nlm.nih.gov/pubmed/9147882. Accessed 8/18/2009.
- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
In Depth Information
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Pachygyria. Click on the link to go to OMIM and review these resources.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Pachygyria. Click on the link to view a sample search on this topic.